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Helping the Body Heal Itself From the Inside Out
2014 Publications
Putative role of protein kinase C in neurotoxic inflammation mediated by extracellular heat shock protein 70 after ischemia-reperfusion.
An adaptive role of TNFα in the regulation of striatal synapses.
AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease.
Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells.
Altered expression of oligodendrocyte and neuronal marker genes predicts the clinical onset of autoimmune encephalomyelitis and indicates the effectiveness of multiple sclerosis-directed therapeutics.
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.
Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia.
Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice.
Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
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