INB16 is the pharmaceutical grade cell line derived from CTV-1 and, although demonstrably different, their effects on resting NK cells are identical


North J, Bakhsh I, Marden C, Pittman H, Addison E, Navarrete C, Anderson R, Lowdell MW. Tumor-primed human natural killer cells lyse NK-resistant tumor targets: evidence for a two-stage process in resting NK cell activation. Journal of Immunology; 178:85-94. PMID: 17182543


Sabry M, Tsirogianni M, Bakhsh IA, North J, Sivakumaran J, Giannopoulos K, Anderson R, Mackinnon S and Lowdell MW. Leukemic priming of resting NK cells is KIR independent but requires CD15-mediated CD2 ligation and natural cytotoxicity receptors. J.Immunology; 187:6227-6234.  doi: 10.4049/jimmunol.1101640
Katodritou E, North J, Kottaridis P, Verrou E, Gastari V,  Chadjiaggelidou C, Sivakumaran J, Jide-Banwo S, Tsirogianni M, Zervas K, Lowdell MW.  Tumor-primed Natural Killer Cells from Patients with Multiple Myeloma Lyse Autologous, NK-resistant, Bone Marrow-derived Malignant Plasma Cells. Am J Hematology; 86:967-973. doi: 10.1002/ajh.22163.


Sabry M, Lowdell MW. Tumour-primed NK cells; waiting for the green light. Frontiers in Immunology; 2013: 4:1-7. doi: 10.3389/fimmu.2013


Kottaridis PD, North, Tsirogianni M, Marden C, Samuel ER, Jide-Banwo S, Grace S, Lowdell MW. Two-stage priming of allogeneic Natural Killer cells for the treatment of patients with acute myeloid leukemia; a phase I trial. PLoS One; Jun 10;10(6):e0123416. doi: 10.1371


Natural killer cells differentiated in vitro from cord blood CD34+ cells are more advantageous for use as an immunotherapy than peripheral blood and cord blood natural killer cells.
Domogala A, Blundell M, Thrasher A, Lowdell MW, Madrigal JA, Saudemont A. Cytotherapy. 2017 Jun;19(6):710-720. doi: 10.1016/j.jcyt.2017.03.068. Epub 2017 Apr 17.


Fehniger TA, Miller JS, Stuart RK, Cooley S, Salhotra A, Curtsinger J, Westervelt P, DiPersio JF, Hillman TM, Silver N, Szarek M, Gorelik L, Lowdell MW, Rowinsky E. A Phase 1 Trial of CNDO-109-Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia. Biology Blood Marrow Transplant 2018:e-pub  doi: 10.1016/j.bbmt.2018.03.019
Doherty E & Rouce RH. Primed to kill: CTV-1 stimulated haploidentical NK cells for consolidation of AML.
Biology Blood Marrow Transplant 2018:e-pub;


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